Effect of prednisolone on serum creatine phosphokinase.

نویسندگان

  • R C Gupta
  • U Gupta
  • J P Garg
چکیده

Determination of serum creatine phos~hokinase (CPK; EC 2.7.3.2.) is important ill laboratory diagnosis of myocardial infarction (M') and skeletal muscle disorders (7). Two recent reports suggest that administration of corticosteroids decreases serum CPK activity (1.5). If patients with MI and myopathies are given. corticosteroids as some of them are the corticostEroids may ~revent the expected rise in serum CPK, or the rise ma'/ be much less than anticirated. This will adversely affect the reliability and sensitivity of serum CPK in the diagnosis of these diseases. We have rer:orted earlier that short-term administration of a corticost( roid (~rednisolone) in the usual dosage (15 to 40 mg/day) does not affect sEtum CPK acti\ity (2). We have now four,d that a longer administration of rredniso'one has ro major effect on serum CPK activity.

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عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 28 3  شماره 

صفحات  -

تاریخ انتشار 1984